| I'm the first to admire the strengths and
| |
| | outcome were minimal to none.3. When they
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| virtues of the free-enterprise model as
| |
| | draw attention away from non-medication
|
| it applies to drug development and sales.
| |
| | treatments.Drug companies sell drugs.
|
| This model encourages drug companies to
| |
| | Therefore, when it comes to marketing
|
| employ talented people and to take risks
| |
| | their products, they have no interest in
|
| in developing new drugs for serious
| |
| | promoting -- or even mentioning --
|
| medical problems. But let's face it,
| |
| | non-drug treatments. There are no
|
| current practices also produce
| |
| | salespeople making the rounds of doctors'
|
| undesirable effects.1. When their drug
| |
| | offices to remind physicians of the
|
| that was wonderful last month is suddenly
| |
| | rigorously proved benefits of stress
|
| no good.It's been entertaining to watch
| |
| | management training for migraine and
|
| the drug companies suddenly come up with
| |
| | tension-type headaches, or of
|
| new, patentable variations of their drugs
| |
| | cognitive-behavioral counseling for
|
| just when their old patents are expiring.
| |
| | depression.4. When they hook us on
|
| For example, since the 1970s, the Abbott
| |
| | samples.Doctors' offices receive samples
|
| company has been doing a dance with
| |
| | of patented (high mark-up) drugs and not
|
| different formulations of valproic acid
| |
| | of unpatented (low mark-up) drugs.
|
| (used for seizures, migraines and bipolar
| |
| | Therefore, patients are steered toward
|
| disorder). At first, the brand name was
| |
| | the expensive drugs by means of these
|
| Depakene, but when that patent ran out,
| |
| | "loss-leaders."5. When they shape medical
|
| Depakene was suddenly no good any more,
| |
| | practice.Drug companies aggressively
|
| and Depakote (just barely different
| |
| | court the thought-leaders, like faculty
|
| enough to be patentable) was the only
| |
| | members at medical schools, with
|
| drug one should think of. Then when
| |
| | financial perks such as impressive fees
|
| Depakote's patent ran out, suddenly it
| |
| | for speaking engagements. They also
|
| wasn't any good, either. Now Depakote ER
| |
| | subsidize medical publications. The
|
| (extended release) is the only way to
| |
| | effects of these marketing activities on
|
| fly.This approach of reworking the old
| |
| | medical practice are not necessarily
|
| drug into longer-acting formats has
| |
| | beneficial to patients.For example,
|
| worked for other drug companies, too. For
| |
| | tissue plasminogen activator (tPA) is an
|
| example, GlaxoSmithKline has gone through
| |
| | expensive clot-dissolving drug approved
|
| the same dance with their formulations of
| |
| | for use in stroke patients. Its benefits
|
| bupropion for depression, evolving from
| |
| | are modest and its risks are real (brain
|
| Wellbutrin to Wellbutrin SR (sustained
| |
| | hemorrhage and death). Thoughtful
|
| release) to Wellbutrin XL (extended
| |
| | clinicians might reasonably conclude that
|
| release). Wyeth, seeing a good thing,
| |
| | the benefits of administering tPA do not
|
| followed the same path with venlafaxine
| |
| | outweigh the risks. But this is not the
|
| antidepressant, going from Effexor to
| |
| | message that comes from many
|
| Effexor XR (extended release). It's just
| |
| | thought-leaders and publications.
|
| an amazing coincidence how these new,
| |
| | Instead, the implication is that
|
| suddenly-better drugs emerge just when
| |
| | administering this drug is a standard of
|
| the old drugs expire and face generic
| |
| | care, and omitting it constitutes
|
| competition.2. When they make us forget
| |
| | malpractice.6. When the sales reps push
|
| that the older drugs work just fine.Since
| |
| | unapproved uses.Recently, a Pfizer sales
|
| 1954 we've had effective anti-psychotic
| |
| | rep told me that his company's drug,
|
| drugs to treat schizophrenia, but
| |
| | pregabalin, is effective in preventing
|
| beginning in the 1990s a series of new
| |
| | migraine. He shouldn't have said that.
|
| anti-psychotics emerged, now called the
| |
| | Pregabalin is FDA-approved for treatment
|
| "atypical" or "novel" anti-psychotics.
| |
| | of epilepsy and nerve-pain, but not
|
| Suddenly, the older drugs -- all generic
| |
| | migraine. Although physicians in the U.S.
|
| and therefore reasonably priced -- were
| |
| | are allowed to prescribe drugs for
|
| no good. Only the new, patented
| |
| | "off-label" uses, drug companies are
|
| anti-psychotics were any good and one
| |
| | prohibited from advertising their drugs
|
| might even be guilty of malpractice if
| |
| | for non-approved uses. In fact, Pfizer
|
| one prescribed an older drug (or
| |
| | got in trouble for pushing another drug,
|
| continued prescribing one to a patient
| |
| | gabapentin, for unapproved uses.7. When
|
| who seemed to be doing fine). Indeed, a
| |
| | doctors don't think critically about what
|
| generation of new psychiatrists cycled
| |
| | they're doing.This, strictly speaking,
|
| through training programs with this
| |
| | isn't a deficiency of the drug companies.
|
| concept in mind, rarely writing a
| |
| | But because the only salespeople that
|
| prescription for an older drug.The
| |
| | doctors see are for expensive, branded
|
| alleged superiority of the newer drugs
| |
| | drugs, the names of less expensive (or
|
| was tested in the recently completed
| |
| | more effective) alternatives may not come
|
| CATIE (Clinical Antipsychotic Trials in
| |
| | to mind when prescriptions are
|
| Intervention Effectiveness) study and
| |
| | written.(C) 2006 by Gary CordingleyGary
|
| found to be absent. The study compared
| |
| | Cordingley, MD, PhD, is a clinical
|
| four newer drugs to an older drug,
| |
| | neurologist, teacher and researcher who
|
| perphenazine, and the differences in
| |
| | works in Athens, Ohio.
|
